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For the statistics of stress reporter assay data, R (3.3.2) (R Core Team, 2017) and nlme (Pinheiro et al., 2009) (nlme: Linear and Nonlinear Mixed Effects Model) was used to perform a linear mixed effect model for longitudinal data with the following call: lme [value time treatment_dose, random = time | plateID, correlation = corAR1 (form = 1 |plateID)]

No serious adverse events have been reported in published studies

TB-500 sequesters G-actin monomers, regulating actin polymerization and thereby controlling cytoskeletal dynamics essential for cell migration

Slack-Davis, J